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Cat. No.	Product Name	Target	Signaling Pathways
T2399	Bortezomib Radiciol,NSC 681239,硼替佐米,MG 341,DPBA,Brotezamide,LDP 341	Apoptosis; NF-κB; Proteasome; Autophagy	Apoptosis; Autophagy; NF-κB; Proteases/Proteasome; Ubiquitination
	Bortezomib (LDP 341) 是一种 20S 蛋白酶体抑制剂 (Ki=0.6 nM)，具有可逆性和选择性。Bortezomib 具有抗肿瘤活性，可以抑制 NF-κB，可破坏细胞周期、诱导细胞凋亡。
T37581	SCIO 469 hydrochloride
	Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells. Hideshima et al (2004) p38 MAPK inhibition enhances P...